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Accupril
hypertension treatment
ACCUPRIL is indicated for the treatment of hypertension. It may be used alone or in combination with thiazide diuretics. ACCUPRIL is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an ACE inhibitor. Angioedema has been reported with ACE inhibitors, including ACCUPRIL.
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Accupril UsesAccupril is used in the treatment of high blood pressure. It can be taken alone or in combination with a thiazide type of water pill such as HydroDIURIL. Accupril is in a family of drugs known as "ACE inhibitors." It works by preventing a chemical in your blood called angiotensin I from converting into a more potent form that increases salt and water retention in your body. Accupril also enhances blood flow throughout your blood vessels. Along with other drugs, Accupril is also prescribed in the treatment of congestive heart failure. You must take Accupril regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Accupril; and you must continue taking it even if you are feeling well. Accupril does not cure high blood pressure; it merely keeps it under control.
Accupril How To TakeYou can take Accupril with or without meals. Alcohol may increase the effect of Accupril, and could cause dizziness or fainting. Avoid alcoholic beverages until you have checked with your doctor. Take Accupril exactly as prescribed, and see your doctor regularly to make sure the drug is working properly without unwanted side effects. Do not stop taking this drug without first consulting your doctor.
Accupril Side EffectsThe most frequent clinical adverse reactions in controlled trials were (in descending order of frequency) headache, dizziness, rhinitis, coughing, upper respiratory tract infection, fatigue, dyspepsia, nausea and vomiting, myalgia, abdominal pain, diarrhoea, insomnia, paresthesia, nervousness, asthenia, hypotension and leucopenia.
Less frequent adverse events that have been reported include: palpitations, vasodilatation, dry mouth or throat, pancreatitis, vertigo, nervousness, depression, somnolence, pruritus, rash, exfoliative dermatitis, pemphigus, increased perspiration, alopecia, urinary tract infection, impotence, edema, arthralgia, hemolytic anaemia, and angioedema.
Creatinine and Blood Urea Nitrogen: Increases (>1,25 times the upper limit of normal) in serum creatinine and blood urea nitrogen may occur especially with concomitant diuretic therapy.
Accupril Medical PrecautionsACE inhibitors such as Accupril have been shown to cause injury and even death to the unborn child when used in pregnancy during the second and third trimesters. If you are pregnant, your doctor should discontinue Accupril as soon as possible. If you plan to become pregnant, make sure your doctor knows you are taking this medication. Accupril appears in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.
Accupril Drug InteractionsTetracycline: Concomitant administration of tetracycline with ACCUPRIL reduced the absorption of tetracycline in healthy volunteers because of the presence of magnesium carbonate in the formulation. It is recommended that concomitant administration of ACCUPRIL and tetracycline be avoided. Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE-inhibitor therapy due to the sodium-losing effect of these agents. These drugs should be administered with caution and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, it may increase the risk of lithium toxicity. Other Agents: No important pharmacokinetic interactions occurred when ACCUPRIL was used concomitantly with propranolol, hydrochlorothiazide, digoxin, or cimetidine. No change in prothrombin time occurred when ACCUPRIL and warfarin were given together. Concomitant Diuretic Therapy: Patients on diuretics, especially those on recently instituted diuretic therapy, may experience an excessive reduction of blood pressure after initiation of therapy with ACCUPRIL. Hypotensive effects after the first dose of ACCUPRIL may be minimized by discontinuing the diuretic a few days prior to initiation of therapy. In patients in whom a diuretic is continued, medical supervision should be provided up to two hours after the initial dosage of ACCUPRIL.
Accupril Medical NotesHIGH BLOOD PRESSURE
The usual starting dose of Accupril is 10 or 20 milligrams taken once a day. If you have any trouble with your kidneys or if you are also taking a diuretic, your starting dose may be lower. For adults over age 65, the usual starting dose is 10 milligrams. Depending on how your blood pressure responds, your doctor may increase your dose up to a total of 80 milligrams a day taken once daily or divided into two doses.
CONGESTIVE HEART FAILURE
The usual starting dose of Accupril is 5 milligrams taken twice a day. Your doctor may increase the dose from week to week, up to as much as 20 to 40 milligrams daily, divided into 2 equal doses. If you have kidney problems, the dosage will be lower.
Accupril Missed DosagesIf you miss a dose of Accupril take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never try to "catch up" by doubling the dose.
Accupril StorageStore in a cool (below 25°C), dry place. Protect from light and moisture. KEEP OUT OF REACH OF CHILDREN.
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